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- Overgrowth, asymmetry, and gigantism of the limbs
- Increased size of an organ, or the body, or bones (hypertrophy)
- Raised rough Skin (verrucous epidermal naevi)
- Deep lines and overgrowth of soft tissue on the soles of the feet (cerebriform connective tissue nevus)
- Patches of overgrown blood or lymphatic vessels (vascular malformations)
- Local overgrowth of fat (lipomas) or undergrowth of fat
- Various tumors are more common in patients with Proteus syndrome, but most are benign
- Deep venous thromboses (blood clots) and the lodging of these blood clots in the lungs (This can be life threatening)
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